Sigma Receptor Activation Mitigates Toxicity Evoked by the Convergence of Ischemia, Acidosis and Amyloid-beta
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Sigma-1 receptor activation prevents intracellular calcium dysregulation in cortical neurons during in vitro ischemia.
Sigma receptors are putative targets for neuroprotection following ischemia; however, little is known on their mechanism of action. One of the key components in the demise of neurons following ischemic injury is the disruption of intracellular calcium homeostasis. Fluorometric calcium imaging was used to examine the effects of sigma receptor activation on changes in intracellular calcium concen...
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تاریخ انتشار 2015